Guide
BPC-157 vs TB-500: what's the difference?
BPC-157 and TB-500 are two distinct research peptides studied in tissue-repair models. Here's how they differ by sequence, size, and research context - and how to verify either.
Published June 4, 2026
BPC-157 and TB-500 are two distinct research peptides. BPC-157 is a 15-amino-acid pentadecapeptide derived from a gastric protein sequence; TB-500 is a synthetic version of the active region of Thymosin Beta-4, a 43-amino-acid peptide. Both are widely studied in tissue and actin-related research models, but they are different molecules - different sequences, different sizes, and different mass-spec targets on a lab report.
This page compares them as research materials only: what each is, how they differ chemically, and how to verify either. It is not guidance for human or animal use, which neither peptide is approved for.
Side by side
| BPC-157 | TB-500 (TB4) | |
|---|---|---|
| Type | Pentadecapeptide (15 aa) | Fragment of Thymosin Beta-4 (43 aa) |
| Origin | Derived from a gastric juice protein sequence | Synthetic version of the active region of TB-4 |
| Studied in | Tissue and gut research models | Actin-binding and tissue-research models |
| Form sold | Lyophilized vial | Lyophilized vial |
| Regulatory status | Research use only | Research use only |
What BPC-157 is
BPC-157 ("Body Protection Compound") is a short, stable peptide based on a sequence found in a gastric protein. It's one of the most-studied research peptides in tissue and gut research models. As a small peptide, it has a single, well-defined mass-spec target - for example, an expected mass around 1419.55 Da - which makes its identity straightforward to confirm on a lab report. You can see a live example on the BPC-157 product page.
What TB-500 is
TB-500 is a synthetic peptide corresponding to the active, actin-binding region of Thymosin Beta-4, a naturally occurring 43-amino-acid peptide. Because it represents a fragment of a larger protein, it's a different molecule from BPC-157 with its own sequence and molecular weight. It's studied in actin-binding and tissue-research models. See the TB-500 product page for its current batch report.
Why they're often combined
Because both are heavily studied in tissue-repair research and are frequently used together in those protocols, they're commonly offered as a single lyophilized blend - see what a peptide blend is and the BPC-157 + TB-500 blend. A blend is purely a packaging convenience: two peptides in one vial you reconstitute together, instead of two separate vials.
How to verify either one
The peptide name tells you nothing about quality - the vial's report does. For both BPC-157 and TB-500, check that the report:
- shows HPLC purity above 95%,
- gives a mass-spec value matching the expected mass for that specific peptide (they're different numbers),
- lists endotoxin under 0.5 EU/mg and a sterility pass,
- names an independent lab with a test date after the fill date.
Every BPC-157, TB-500, and blend vial in the pepuro catalog carries a QR code that resolves to its own report at pepuro.com/b/<batch code>, so you verify the exact vial rather than the peptide in the abstract. (How per-vial QR tracking works.)
For research use only. Not for human or animal consumption.
Frequently asked questions
Are BPC-157 and TB-500 the same thing?+
No. They are two different molecules. BPC-157 is a 15-amino-acid peptide derived from a gastric protein sequence; TB-500 is a synthetic fragment of Thymosin Beta-4, a 43-amino-acid peptide. They have different sequences and different molecular weights.
Why are BPC-157 and TB-500 sold together as a blend?+
They're two of the most-studied research peptides and are commonly paired in tissue-repair research protocols, so some suppliers offer them lyophilized together in a single vial for convenience. The blend is one vial you reconstitute together rather than two separate vials.
Which one is purer or higher quality?+
Quality is per-vial, not per-peptide. Both should arrive with a third-party report showing HPLC purity above 95% and a matching mass-spec identity. Judge the specific vial's report, not the peptide name.
Do BPC-157 and TB-500 have different molecular weights?+
Yes. They're different sizes - BPC-157 is a 15-residue peptide and TB-500 is a fragment of a 43-residue protein - so their mass-spec target values on a lab report are different. Always check the observed mass against the expected value for that specific peptide.
Are these approved for human use?+
No. Both are research-use-only materials, not approved by Health Canada or the FDA for human or animal use. They are sold and should be handled strictly as research chemicals.
Related articles
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- What you actually pay importing research peptides from the USDuty is waived under CAD $150, but sales tax starts at CAD $40 and carrier brokerage is charged on top. The full cost stack of a cross-border order, and the parts that are not money.
- Keeping research records in Kingston when nobody files them for youOrdering directly means the documentation is yours to keep. What Kingston researchers should retain, and why a report attached to the vial beats one lost in an inbox.
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