BPC-157 vs TB-500: what's the difference?

BPC-157 and TB-500 are two distinct research peptides. BPC-157 is a 15-amino-acid pentadecapeptide derived from a gastric protein sequence; TB-500 is a synthetic version of the active region of Thymosin Beta-4, a 43-amino-acid peptide. Both are widely studied in tissue and actin-related research models, but they are different molecules — different sequences, different sizes, and different mass-spec targets on a lab report.

This page compares them as research materials only: what each is, how they differ chemically, and how to verify either. It is not guidance for human or animal use, which neither peptide is approved for.

Side by side

What BPC-157 is

BPC-157 ("Body Protection Compound") is a short, stable peptide based on a sequence found in a gastric protein. It's one of the most-studied research peptides in tissue and gut research models. As a small peptide, it has a single, well-defined mass-spec target — for example, an expected mass around 1419.55 Da — which makes its identity straightforward to confirm on a lab report. You can see a live example on the BPC-157 product page.

What TB-500 is

TB-500 is a synthetic peptide corresponding to the active, actin-binding region of Thymosin Beta-4, a naturally occurring 43-amino-acid peptide. Because it represents a fragment of a larger protein, it's a different molecule from BPC-157 with its own sequence and molecular weight. It's studied in actin-binding and tissue-research models. See the TB-500 product page for its current batch report.

Why they're often combined

Because both are heavily studied in tissue-repair research and are frequently used together in those protocols, they're commonly offered as a single lyophilized blend — see what a peptide blend is and the BPC-157 + TB-500 blend. A blend is purely a packaging convenience: two peptides in one vial you reconstitute together, instead of two separate vials.

How to verify either one

The peptide name tells you nothing about quality — the vial's report does. For both BPC-157 and TB-500, check that the report:

• shows HPLC purity above 95%,
• gives a mass-spec value matching the expected mass for that specific peptide (they're different numbers),
• lists endotoxin under 0.5 EU/mg and a sterility pass,
• names an independent lab with a test date after the fill date.

Every BPC-157, TB-500, and blend vial in the pepuro catalog carries a QR code that resolves to its own report at pepuro.com/v/<uuid>, so you verify the exact vial rather than the peptide in the abstract. (How per-vial QR tracking works.)

For research use only. Not for human or animal consumption.