Guide

Sermorelin vs tesamorelin vs CJC-1295

Three GHRH analogs built on the same fragment, each stabilised a different way. Masses, modifications and what tells them apart.

Published September 4, 2026

Growth-hormone-releasing hormone is 44 residues long, and the first 29 carry the full activity. Three of the four peptides here are built on those 29.

Peptide	Vial sizes	From
Sermorelin	10mg	$77.99 CAD
Tesamorelin	10mg	$77.99 CAD
CJC-1295 (NO-DAC)	Single size	$34.99 CAD
CJC-1295 (DAC)	Single size	$42.99 CAD

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Same starting point, three treatments

Sermorelin is GHRH(1-29) with nothing added. It is the baseline: the shortest fragment that still works, unmodified, and correspondingly quick to be cleared.

CJC-1295 takes the same 29-residue fragment and swaps four amino acids for ones the trimming enzyme cannot cut. That is the no-DAC version. Add a drug affinity complex that binds albumin and you get the DAC version, which lasts far longer in research models. CJC-1295 DAC vs no-DAC goes through that pair in detail.

Tesamorelin goes the other way: keep all 44 residues and stabilise the N-terminus with a trans-3-hexenoyl group. It is the heaviest of the four by a wide margin.

The numbers

	Basis	Molecular weight	CAS
Sermorelin	GHRH(1-29), unmodified	3357.88 g/mol	86168-78-7
CJC-1295 no-DAC	GHRH(1-29), 4 substitutions	3367.90 g/mol	Listings conflict
CJC-1295 DAC	The above, plus DAC	3647.15 g/mol	863288-34-0
Tesamorelin	GHRH(1-44), N-terminal group	5135.90 g/mol	218949-48-5

Sermorelin and CJC-1295 no-DAC are ten grams per mole apart, the tightest pair we sell. Four amino acid substitutions barely change the mass because the residues swapped in are similar in size to the ones swapped out. A mass-spec result to two decimal places still separates them, but this is a case where you should read the report rather than glance at it, and check that the certificate names the compound it tested.

Pairing with a ghrelin agonist

These act at the GHRH receptor. The ghrelin agonists act somewhere else, which is why protocols study one of each rather than choosing. GHRP-2 vs GHRP-6 vs ipamorelin covers that other half.

Reconstitution

Vial	1 mL	2 mL	3 mL	5 mL
10 mg	10 mg/mL2.98 mM	5 mg/mL1.49 mM	3.33 mg/mL0.993 mM	2 mg/mL0.596 mM

Sermorelin vial sizes we sell, at four diluent volumes. Molarity uses 3357.88 g/mol. Other volumes

Tesamorelin is 53% heavier, so the same mass is a third fewer molecules. Its calculator page has the weight preset.

Tell them apart

Sermorelin is the plain 29-residue fragment. CJC-1295 is that fragment made durable, twice over. Tesamorelin is the full 44 residues with a cap. Masses: 3,358, 3,368, 3,647, 5,136.

For research use only. Not for human or animal consumption.

Frequently asked questions

What do sermorelin, tesamorelin and CJC-1295 have in common?+

All three are analogs of growth-hormone-releasing hormone. Sermorelin is GHRH(1-29) unmodified. Tesamorelin is GHRH(1-44) with an N-terminal group added. CJC-1295 is GHRH(1-29) with four amino acid substitutions, and optionally a drug affinity complex.

Which is the plain one?+

Sermorelin. It is the shortest fragment of GHRH that keeps full activity, with nothing added. The other two are stabilised versions, which is why they weigh more.

How much do they differ in mass?+

Sermorelin is 3,357.88 g/mol, CJC-1295 no-DAC is 3,367.90, CJC-1295 DAC is 3,647.15, and tesamorelin is 5,135.90. The first two are only ten apart, so read the observed mass carefully.

Why is tesamorelin so much heavier?+

Because it is the full 44-residue hormone rather than the 29-residue fragment, plus its trans-3-hexenoyl group. Fifteen extra residues is most of the 1,800 g/mol difference.

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