CJC-1295 and ipamorelin vs tesamorelin

CJC-1295 and ipamorelin is a pair of peptides acting at two different receptors, while tesamorelin is a single peptide acting at one of them, so the fair comparison is tesamorelin against the CJC-1295 half of the pair. Both CJC-1295 and tesamorelin are analogs of growth-hormone-releasing hormone (GHRH). Ipamorelin is a ghrelin receptor agonist, and a tesamorelin vial has nothing in its place. IGF-1 LR3 turns up in the same searches, and it belongs to a different part of the pathway altogether.

What is in each vial

The blend is 1:1 by mass and covers two receptors in one vial. CJC-1295 and ipamorelin explains why the two are studied together and gives molar concentrations after reconstitution. A tesamorelin vial covers the GHRH receptor only.

Tesamorelin vs CJC-1295: the GHRH half

GHRH is 44 residues long, and the first 29 carry its full activity. The two analogs take that hormone in opposite directions.

• CJC-1295 no-DAC, also sold as Modified GRF (1-29), keeps the first 29 residues and swaps four amino acids for ones the trimming enzyme cannot cut. With no drug affinity complex, its half-life in research models is around 30 minutes.
• Tesamorelin keeps all 44 residues and caps the N-terminus with a trans-3-hexenoyl group to slow enzymatic breakdown.

Tesamorelin is 53% heavier, mostly because of the 15 extra residues. Sermorelin vs tesamorelin vs CJC-1295 sets both against sermorelin, the unmodified 29-residue fragment. The blend uses the no-DAC form, and CJC-1295 DAC vs no-DAC covers how the two forms differ.

Tesamorelin can also take CJC-1295's place next to ipamorelin. We sell a tesamorelin and ipamorelin blend, 1:1 by mass, in 5 mg + 5 mg and 10 mg + 10 mg vials. Tesamorelin and ipamorelin covers that pairing.

CJC-1295 and ipamorelin vs IGF-1 LR3

The two searches overlap because all three molecules sit on the growth-hormone axis, but at different points on it. CJC-1295 and ipamorelin are secretagogues: they act at receptors that signal for growth-hormone release. Insulin-like growth factor 1 sits downstream of growth hormone, and IGF-1 LR3 is an analog of that downstream hormone.

IGF-1 LR3, CAS 946870-92-4, carries an arginine substitution at position 3 and a 13-residue extension at the N-terminus. Both lower its affinity for IGF-binding proteins, which leaves more of the peptide free in research models. It is studied in cell-growth and IGF-signalling research. At 9117.60 g/mol it is the largest molecule on this page, and it is sold in far smaller vials.

Same milligrams, different molecule counts

Label figures are in milligrams, but IGF-1 LR3 is 12.8 times heavier than ipamorelin, so the same label figure holds very different numbers of molecules.

A 10 mg blend vial holds the first two rows. A 5 mg tesamorelin vial holds about two thirds as many GHRH-analog molecules as the CJC-1295 half of that blend. The ipamorelin handling guide has reconstitution and storage notes, and what is a peptide blend? covers what a blended vial does and does not tell you.

Checking the vial

Each of these peptides has a distinct mass, so the observed-mass line on a lab report separates them:

• CJC-1295 no-DAC near 3367.90
• ipamorelin near 711.85
• tesamorelin near 5135.90
• IGF-1 LR3 near 9117.60

A blend report should list two peptides, each with its own mass and purity line, and state the ratio measured for that batch. How to read a peptide lab report walks through each field.

Every CJC-1295 and ipamorelin vial from pepuro ships free, from our Calgary, Toronto and Vancouver distribution centers, the same business day your e-Transfer clears, with a QR code on the vial that opens its independent, third-party lab report.

For research use only. Not for human or animal consumption.