Guide
Cagrilintide vs Semaglutide: amylin analog vs GLP-1 analog
They are paired in research, not interchanged. Cagrilintide acts at amylin and calcitonin receptors; semaglutide at the GLP-1 receptor. Different hormones, different masses.
Published September 4, 2026
Cagrilintide is not a GLP-1 peptide. It is a long-acting amylin analog that acts at amylin and calcitonin receptors. Semaglutide is a GLP-1 receptor agonist. They sit together on this site because research pairs them, one signal each, not because one replaces the other.
Different hormones
Amylin is a 37-residue hormone released with insulin. Cagrilintide is an engineered analog of it, lipidated so it lasts in research models the way semaglutide's fatty chain makes GLP-1 last. Its receptors are the amylin receptors, which are calcitonin receptors paired with accessory proteins.
Semaglutide is an analog of GLP-1, a different hormone acting at a different receptor. The two peptides do not compete for a binding site. That is the reason they are studied together.
What the two vials hold
| Cagrilintide | Semaglutide | |
|---|---|---|
| Analog of | Amylin | GLP-1 |
| Receptors | Amylin, calcitonin | GLP-1 |
| Formula | C194H310N54O59 | C187H291N45O59 |
| Molecular weight | 4425.00 g/mol (reference, pending COA) | 4113.58 g/mol |
| Vial sizes | 5 mg | 5, 10, 20, 30 mg |
The cagrilintide mass is a reference value until a certificate confirms it. The vial's own lab report carries the observed mass and is the number that counts.
Paired means two vials
A pairing in the literature is two molecules at two concentrations, chosen for the model. That means two vials, two reports and two concentrations worked out separately. The calculator does each, and peptide blends explained covers why fixed-ratio blends suit some work and not others.
| Peptide | Vial sizes | From |
|---|---|---|
| Cagrilintide | 5mg | $60.99 CAD |
| Semaglutide | 5mg, 10mg, 20mg, 30mg | $42.99 CAD |
Free shipping across Canada. Every vial ships with a QR code linking to its own batch lab report. See all peptides
Not a substitute
Cagrilintide is the amylin analog. Semaglutide is the GLP-1 analog. Different receptors, different masses, studied together and bought separately.
For research use only. Not for human or animal consumption.
Frequently asked questions
Is cagrilintide a GLP-1 peptide?+
No. Cagrilintide is a long-acting amylin analog. It acts at amylin and calcitonin receptors, not the GLP-1 receptor. It is listed with the GLP-1 peptides on this site because it is studied alongside them, not because it is one.
Why are cagrilintide and semaglutide paired in research?+
Because they act on different receptor systems. Pairing an amylin analog with a GLP-1 analog lets a model test two signals at once. Each is a separate vial with its own lab report.
What is cagrilintide's molecular weight?+
The reference value on file is 4425.00 g/mol with formula C194H310N54O59, pending confirmation against a certificate. Semaglutide is 4113.58 g/mol.
Do they reconstitute the same way?+
Yes. Both are lipidated peptides supplied as lyophilized powder. Water down the glass, swirl, wait. The calculator gives mg/mL for either.
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